https://www.bobadillalab.com/research-topics daily 0.75 2022-03-02 https://www.bobadillalab.com/research-topics/polyreward-models monthly 0.5 2022-03-29 https://images.squarespace-cdn.com/content/v1/618ec5ff616a160310563883/2c36879e-6f7f-4cba-b0a3-dc5aa81ce587/project2-figure1.png Research Topics - Polyreward models - Make it stand out Dual cocaine and sucrose self-administration (SA) model and reward-specific ensemble tagging, modified from Bobadilla et al., 2020. A) Dual cocaine (coc) / sucrose (suc) self-administration (SA), *p< 0.05 comparing active to inactive Nose pokes (NP). B) Reward-specific seeking, as measured through reinstatement to either the cocaine-cue only (cocaine-cue RST) or the sucrose-cue only (sucrose cue RST), after dual cocaine and sucrose self-administration (SA) and extinction (Ext). In both cases, mice poked significantly more the port associated with the reward of the presented cue. C) Schematic of cocaine- and sucrose-seeking ensembles, overlapping ensembles (active during seeking for both rewards) and non-ensemble cells (non-active during seeking) in the NAcore. Results show the cocaine- and sucrose-seeking ensembles recruit ~0.7% of neurons in the NAcore. In the dual cocaine and sucrose self-administration model, reward-specific ensembles overlap by only ~30%. Schematic by graduate student Carl Litif, MS. https://www.bobadillalab.com/research-topics/psychedelic-compounds monthly 0.5 2022-03-29 https://images.squarespace-cdn.com/content/v1/618ec5ff616a160310563883/3854d0bb-4c22-4b70-8bfb-0848d6d5f779/project3.png Research Topics - Psychedelic compounds - Make it stand out Credit: Denis Pobytov https://www.bobadillalab.com/research-topics/cocaine-seeking-neuronal-ensembles monthly 0.5 2022-03-29 https://images.squarespace-cdn.com/content/v1/618ec5ff616a160310563883/240414b7-9137-4b59-b87d-429d8fb16b34/project1figure1.jpg Research Topics - Cocaine-seeking neuronal ensembles - Make it stand out In this figure, we see expression of the designer receptors exclusively activated by a designer drug (DREADD) virus, tagged in yellow, or mCitrine, allowing us to activate (Gq-DREADD) or silence (Gi-DREADD) the cocaine-seeking ensemble (tagged in red, or Tomato) to show the role of the ensemble on seeking behavior. *=Tom+ mCitrine+ cell, bar= 20 μm. https://images.squarespace-cdn.com/content/v1/618ec5ff616a160310563883/b5f248dc-99c2-46aa-8a33-81a1c4b18c81/project1-figure2.png Research Topics - Cocaine-seeking neuronal ensembles - Make it stand out Ensemble-specific structural spine plasticity measurements. cFos-TRAP2 neuron tagged during cocaine seeking reveals adequate morphology to measure spine plasticity. 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